CARTAGE criteria and indicators for monitoring the progress towards objectives

CARTAGE DELIVERABLES     
  WP1 WP2 WP3 WP4 WP5
2015 Telomere lengths in
muscle, leucocytes
and endothelial
progenitor cells from
atherosclerotic
patients and controls
Basic requirements for
biobank collection
multidisciplinary
staff meeting on
CV ageing
samples selection
to identify new
biomarkers
Definition of joint CV
ageing research
projects
Compilation of current
programs pertaining to
the study of CV ageing
(Masters level)
2016 Analysis of the
methylation of DNA
extracted from
Stanislas cohort
individuals
Definition of the
specific role of
integrin in vascular
smooth muscle cells
in the coupling
between stiffness and
thrombin generation
Harmonization of all cohort
databases including
imaging
Free breathing of 3D
imaging at 3T, of T1 and
T2 mapping and of tissue
characteriza-tion at 3T
Experimental validation of
ß and TREM imaging
Reports on current
clinical practices,
care and
therapeutics
Selection of
cohorts to study
(biomarkers, the
biomarker)
Recruitment of the first
2 Masters students or
postdoctoral fellows
First application for
grants on joint CV
ageing research
projects
Summer school in CV
ageing research
Creation of CV ageing
and geriatric MOOC
2017 MR: within the
framework of the EU
FP7 Fibrotargets
2013-2017
Deciphering the role
of histones in the
anti-phospholipid
syndrome
Setup of new
mechanically
competent vascular
substitutes
Guidelines and toolset to
establish new cohorts
including regulatory, ethical
and valorization issues.
Merging 3D images for
multi-parametric analysis of
CV ageing and of targeted
organs (brain, kidneys)
whole-body CV PET
mapping of active
calcification, angiogenesis
and inflammation.
Good practices &
recommendations
for the management
of CV
ageing diseases.
End of sample
collection
Recruitment of first
PhD students
Creation of a
University diploma
(DIU) in translational
CV ageing research
Creating university
credits in clinical
research for nurses
Development of
simulation-based
mannequin geriatric
teaching in the existing
center : nurses
professional
development and
student training
2018 Establishing dedicated
software for decision
support system
New cohorts and biobanks
ready for clinical trials and
research projects
First CV ageing
clinical trial
funding requests
First joint publication
in CV ageing research
International CV
ageing research meeting in Nancy
2019 First patient included
in a clinical trial
Participation of the
cohorts/biobank in the
clinical trial
  Creation of a first
CARTAGE research team in CV ageing research
Creation of a Masters
degree dedicated to CV
ageing
SUCCESS
INDICATORS
Number of validated
pathophysiological
in vitro, ex vivo and
animal models
Identification of new
targets and corresponding
pathways in
cardiovascular ageing
Completion of major CV
ageing diseases clinical
trials coord from
CARTAGE (industry and
academic)
Systematization
of
multidisciplinary
clinical meetings
Number of grants obtained in CV ageing
Number of researchers recruited in CV ageing
Number of grants
obtained in CV
ageing
Number of
researchers recruited
in CV ageing

FHU-CARTAGE © 2015 - BY MLCOM

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