The main research areas of the team

Clinical cardiologists, EMS providers, geriatric specialists, cardiac insufficiency resuscitation experts and/ or rhythm disorder experts, expert fundamental researchers in cardiac remodelling in heart failure, expert pharmacist-biologists in the detection of biomarkers (all connected to the Clinical Research Unit (URC) and the Biological Resource Centre (CRB) of the site) are brought together by the research theme of the team, which is to:
  1. Identify single or multiple diagnostic markers and/or predictive of risk of progression (death, heart failure, rhythm disorders) in cardiac insufficiency or rhythm disorders, tested both in animals and patients and study pathways of the production or action of these markers in experimental models.
  2. Validate these identified biomarkers of interest and compare them with those currently used clinically (especially in cardiac imaging, physiological effort tests), on our single or multicentre cohorts of patients perfectly phenotyped with acute or chronic cardiac insufficiency or with serious rhythm disorders.

This research topic involves techniques related to biochemistry, physiology, and immunology, analysis of electrical signals or imaging


Adress

INSERM Unité mixte de recherche 942
BIOCANVAS

Hôpital Lariboisière
(Bâtiment Viggo Petersen)
41, boulevard de la Chapelle
75475 Paris Cedex 10

33 942 


Publications

  • 2015
  1. Vergaro G, Del Franco A, Giannoni A, Prontera C, Ripoli A, Barison A, Masci PG, Aquaro GD, Cohen Solal A, Padeletti L, Passino C, Emdin M. Galectin-3 and myocardial fibrosis in nonischemic dilated cardiomyopathy. Int J Cardiol. 2015 Feb 10;184C:96-100. doi: 10.1016/j.ijcard.2015.02.008. [Epub ahead of print] PubMed PMID: 25697876.
  2. Seronde MF, Laribi S, Collins SP, Deye N, Logeart D, Plaisance P, Cohen-Solal  A, Mebazaa A. Heart failure diagnosis in acute conditions has high agreement with inpatient diagnosis. Eur J Emerg Med. 2015 Feb 23. [Epub ahead of print] PubMed PMID: 25647039.
  3. Vodovar N, Paquet C, Mebazaa A, Launay JM, Hugon J, Cohen-Solal A. Neprilysin, cardiovascular, and Alzheimer's diseases: the therapeutic split? Eur Heart J. 2015 Jan 29. pii: ehv015. [Epub ahead of print] Review. PubMed PMID: 25636748.
  4. Cohen-Solal A, Laribi S, Ishihara S, Vergaro G, Baudet M, Logeart D, Mebazaa A, Gayat E, Vodovar N, Pascual-Figal DA, Seronde MF. Prognostic markers of acute  decompensated heart failure: the emerging roles of cardiac biomarkers and prognostic scores. Arch Cardiovasc Dis. 2015 Jan;108(1):64-74. doi: 10.1016/j.acvd.2014.10.002. Epub 2014 Nov 4. PubMed PMID: 25534886.
  • 2014
  1. Vodovar N, Séronde MF, Laribi S, Gayat E, Lassus J, Boukef R, Nouira S, Manivet P, Samuel JL, Logeart D, Ishihara S, Cohen Solal A, Januzzi JL Jr, Richards AM, Launay JM, Mebazaa A; GREAT Network. Post-translational modifications enhance NT-proBNP and BNP production in acute decompensated heart failure. Eur Heart J. 2014 Dec 21;35(48):3434-41. doi: 10.1093/eurheartj/ehu314.  Epub 2014 Aug 24. PubMed PMID: 25157115.
  2. Cohen-Solal A, Leclercq C, Deray G, Lasocki S, Zambrowski JJ, Mebazaa A, de Groote P, Damy T, Galinier M. Iron deficiency: an emerging therapeutic target in  heart failure. Heart. 2014 Sep 15;100(18):1414-20. doi: 10.1136/heartjnl-2014-305669. Epub 2014 Jun 23. Review. PubMed PMID: 24957529.
  3. Laribi S, Aouba A, Resche-Rigon M, Johansen H, Eb M, Peacock FW, Masip J, Ezekowitz JA, Cohen-Solal A, Jougla E, Plaisance P, Mebazaa A. Trends in death attributed to myocardial infarction, heart failure and pulmonary embolism in Europe and Canada over the last decade. QJM. 2014 Oct;107(10):813-20. doi: 10.1093/qjmed/hcu083. Epub 2014 Apr 11. PubMed PMID: 24729266.
  4. Shah R, Gayat E, Januzzi JL Jr, Sato N, Cohen-Solal A, diSomma S, Fairman E,  Harjola VP, Ishihara S, Lassus J, Maggioni A, Metra M, Mueller C, Mueller T, Parenica J, Pascual-Figal D, Peacock WF, Spinar J, van Kimmenade R, Mebazaa A; GREAT (Global Research on Acute Conditions Team) Network. Body mass index and mortality in acutely decompensated heart failure across the world: a global obesity paradox. J Am Coll Cardiol. 2014 Mar 4;63(8):778-85. doi: 10.1016/j.jacc.2013.09.072. Epub 2013 Dec 4. PubMed PMID: 24315906.
  5. Cohen A, Assyag P, Boyer-Chatenet L, Cohen-Solal A, Perdrix C, Dalichampt M,  Michel PL, Montalescot G, Ravaud P, Steg PG, Boutron I; Réseau Insuffisance Cardiaque (RESICARD) PREVENTION Investigators. An education program for risk factor management after an acute coronary syndrome: a randomized clinical trial.  JAMA Intern Med. 2014 Jan;174(1):40-8. doi: 10.1001/jamainternmed.2013.11342. PubMed PMID: 24126705.
  6. Dobre D, Borer JS, Fox K, Swedberg K, Adams KF, Cleland JG, Cohen-Solal A, Gheorghiade M, Gueyffier F, O'Connor CM, Fiuzat M, Patak A, Piña IL, Rosano G, Sabbah HN, Tavazzi L, Zannad F. Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties. Eur J Heart Fail. 2014 Jan;16(1):76-85. doi: 10.1093/eurjhf/hft129. Epub 2013 Dec 3. Review. PubMed PMID: 23928650.
  7. Fazal L, Azibani F, Vodovar N, Cohen Solal A, Delcayre C, Samuel JL. Effects of biological sex on the pathophysiology of the heart. Br J Pharmacol. 2014 Feb;171(3):555-66. doi: 10.1111/bph.12279. Review. PubMed PMID: 23763376; PubMed Central PMCID: PMC3969072.

 

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