The main research areas of the team

ARTERIAL AGING: Geriatrics – CIC - INSERM U1116 (L. Joly, A. Kearney-Schwartz, G. Watfa, C. Labat, S. Gautier, C. Cakir-Kiefer (contrat d'interface), D. Lambert (Thésard), A. Bénétos)

  • Validation of new approaches for the assessment of arterial risk in elderly and delicate patients. Inflamm,ation and arterial stiffness. (More than 50 publications over a 10-year period)

TELOMERES: Geriatrics- INSERM U1116 (S. Toupance, S. Gautier, G. Watfa, P. Lacolley, A. Bénétos)

  • Telomere dynamics and accelerated vascular aging.
  • PROJECT: ANR TRANSLATIONELLE TELARTA (Telomeres and Arterial Aging)

QUALITY OF LIFE: Geriatrics- EA4360 APEMAC - CMRR- USP (C. Perret-Guillaume, JY. Niemier, Th. Jonveaux)

  • Perceived health, well-being, and therapeutic preferences among the elderly.

Alzheimer's disease and Related Disorders: CMRR - (Th. Jonveaux, A. Besozzi, G. Watfa, A. Bénétos)

  • New treatments (BACE and MAYFLOWER (MAyflOwer RoAD Study) International Studies)
  • New biomarkers (MEMENTO National Study)
  • Non-drug related management (REMAD, JAZ STOP, JAZ ART Studies)
  • Vascular component (National PHRC ADELAHYDE II)


CHU de Nancy
29, avenue du Maréchal de Lattre de Tassigny
CO 60034 - 54035 NANCY CEDEX

Director: Professor Athanase Benetos
Chairman of Geriatrics, at the University of Nancy, France
Senior Researcher at INSERM (National Institute of Biomedical Research) Unit 1116

a benetos


  1. JOLY L, DJABALLAH W, KOEHL G, MANDRY D, DOLIVET G, MARIE PY, BENETOS A. Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification. Eur J Nucl Med Mol Imaging. 2009;36:979-85
  2. JOLY L, PERRET-GUILLAUME C, KEARNEY-SCHWARTZ A, SALVI P, MANDRY D, MARIE PY, KARCHER G, ROSSIGNOL P, ZANNAD F, BENETOS A. Pulse wave velocity assessment by external noninvasive devices and phase-contrast magnetic resonance imaging in the obese. Hypertension. 2009;54:421-6.
  3. BENETOS A, THOMAS F, JOLY L, BLACHER J, PANNIER B, LABAT C, SALVI P, SMULYAN H, SAFAR ME. Pulse pressure amplification, a mechanical biomarker of cardiovascular risk. J Am Coll Cardiol. 2010;55:1032-7.
  4. BENETOS A, KIMURA M, LABAT C, BUCHOFF GM, HUBER S, LABAT L, LU X, AVIV A. A model of canine leukocyte telomere dynamics. Aging Cell. 2011;10:991-5.
  5. BENETOS A, LACOLLEY P. How to assess the link between vascular biology and arterial hemodynamics? Hypertension. 2012;59:769-70.
  6. BENETOS A, GAUTIER S, LABAT C, SALVI P, VALBUSA F, MARINO F, TOULZA O, AGNOLETTI D, ZAMBONI M, DUBAIL D, MANCKOUNDIA P, ROLLAND Y, HANON O, PERRET-GUILLAUME C, LACOLLEY P, SAFAR ME, GUILLEMIN F. Mortality and cardiovascular events are best predicted by low central/peripheral pulse pressure amplification but not by high blood pressure levels in elderly nursing home subjects: the PARTAGE study. J Am Coll Cardiol. 2012;60:1503-11.
  7. DANIALI L, BENETOS A, KARK J LABAT C, KIMURA M, DESAI K, GRANICK M, AVIV A Telomeres Shorten at Equivalent Rates in Somatic Tissues of Adults. Nature Commun. 2013;4:1597. doi: 10.1038
    BENETOS A, KARK J, SUSSER E, KIMURA M, SINNREICH R, CHEN W, STEENSTRUP T, CHRISTENSEN K, HERBIG U, VON BORNEMANN HJELMBORG J, SRINIVASAN SR, BERENSON GS, LABAT C, AVIV A. Tracking and Fixed Ranking of Leukocyte Telomere Length across the Adult Life Course. Aging Cell. 2013; 12:615-21
  8. WATFA G, BENETOS A, KEARNEY-SCHWARTZ A, LABAT C, GAUTIER S, HANON O, SALVI P, JOLY L; PARTAGE study investigators. Do Arterial Hemodynamic Parameters Predict Cognitive Decline Over a Period of 2 Years in Individuals Older Than 80 Years Living in Nursing Homes? The PARTAGE Study. J Am Med Dir Assoc. 2015 Mar 14. pii: S1525-8610(15)00105-X. doi: 10.1016/j.jamda.2015.01.098.
  9. BENETOS A, LABAT C, ROSSIGNOL P, FAY R, ROLLAND Y, VALBUSA F, SALVI P, ZAMBONI M, MANCKOUNDIA P, HANON O, GAUTIER S. Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents: The PARTAGE Study. JAMA Intern Med. 2015 Feb 16. doi: 10.1001/jamainternmed.2014.8012.


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