Thematic areas

Our unit is organized in 2 teams one entitled “Hypercoagulability, arterial stiffness and ageing” and the other “Shock, heart failure: cardiovascular mechanisms and treatment”.
The project of Team 1 is centred on the study of vascular stiffening and hypercoagulable phenotypes as well as on telomere dynamics and inflammation in arterial ageing.
The projects of Team 2 are centred on the 
response to acute injury or on the chronic transition to heart failure and their consequences on cardiac and vascular function, and on the study of treatments which may modulate this response or transition. The therapeutic application aims at providing the physician with markers which can help not only to stratify risks but also to determine their nature in order to select therapeutic strategies based on mechanistic biomarker profiles (bio-targets). 
INSERM U1116 P. Lacolley


Faculté de Médecine
9 avenue de la forêt de Haye
CS 50184
54505 Vandoeuvre les Nancy Cedex

Tel: 00 33 (0) 3 83 68 36 21  / Fax: 00 33 (0) 6 86 85 51 63
Secretariat : 00 33 (0) 3 83 68 36 23


  1. Eschalier R, Rossignol P, Kearney-Schwartz A, Adamopoulos C, Karatzidou K, Fay R, Mandry D, Marie PY, Zannad F. Features of cardiac remodeling, associated with blood pressure and fibrosis biomarkers, are frequent in subjects with abdominal obesity. Hypertension. 2014;63:740-6.
  2. Regnault V, Lagrange J, Pizard A, Safar ME, Fay R, Pitt B, Challande P, Rossignol P, Zannad F, Lacolley P. Opposite predictive value of pulse pressure and aortic pulse wave velocity on heart failure with reduced left ventricular ejection fraction: insights from an Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) substudy. Hypertension. 2014 Jan;63(1):105-11.
  3. Lagrange J, Li Z, Fassot C, Bourhim M, Louis H, Nguyen Dinh Cat A, Parlakian A, Wahl D, Lacolley P, Jaisser F, Regnault V. Endothelial mineralocorticoid receptor activation enhances endothelial protein C receptor and decreases vascular thrombosis in mice. FASEB J. 2014 May;28(5):2062-72.
  4. Ait Aissa K, Lagrange J, Mohamadi A, Louis H, Houppert B, Challande P, Wahl D, Lacolley P, Regnault V. Vascular smooth muscle cells are responsible for a prothrombotic phenotype of spontaneously hypertensive rat arteries. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):930-7.
  5. Galmiche G, Labat C, Mericskay M, Aissa KA, Blanc J, Retailleau K, Bourhim M, Coletti D, Loufrani L, Gao-Li J, Feil R, Challande P, Henrion D, Decaux JF, Regnault V, Lacolley P, Li Z. Inactivation of serum response factor contributes to decrease vascular muscular tone and arterial stiffness in mice. Circ Res. 2013 Mar 29;112(7):1035-45.
  6. Boufenzer A, Lemarie J, Simon T, Derive M, Bouazza Y, Tran NN, Maskali F, Groubatch F, Bonnin P, Bastien C, Bruneval P, Marie PY, Cohen R, Danchin N, Silvestre JS, Ait-Oufella H, Gibot S. TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Circ Res. 2015 Apr 3. pii: CIRCRESAHA.114.305628. [Epub ahead of print] PubMed PMID: 25840803.
  7. Morel O, Mandry D, Micard E, Kauffmann C, Lamiral Z, Verger A, Mathias E, Mathias J, Karcher G, Meneroux B, Rossignol P, Marie PY. Evidence of cyclic changes in the metabolism of abdominal aortic aneurysms during growth phases: a FDG-PET sequential observational study. J Nucl Med. 2015 Mar 19. pii: jnumed.114.146415. [Epub ahead of print] PubMed PMID: 25791991.
  8. Kimmoun A, Louis H, Al Kattani N, Delemazure J, Dessalles N, Wei, C, Marie PY, Issa K, Levy B. Βeta-1 adrenergic inhibition improves cardiac and vascular function in experimental septic shock. Crit Care Med. 2015; in press.
  9. Zuily S, de Laat B, Mohamed S, Kelchtermans H, Shums Z, Albesa R, Norman G, Lamboux-Matthieu C, Rat AC, Ninet J, Magy-Bertrand N, Pasquali JL, Lambert M, Lorcerie B, Kaminsky P, Guillemin F, Regnault V, Wahl D, for the TAC(I)T investigators. Validity of the global anti-phospholipid syndrome score to predict thrombosis. A prospective multicentre cohort study. Rheumatology, in press



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